肝癌靶向药物相关手足皮肤反应预防与管理的最佳证据总结 [中文引用][英文引用]

目的 总结肝癌靶向药物相关手足皮肤反应（hand-foot skin reaction ，HFSR）预防及管理措施的相关证据，为临床管理肝癌靶向药物相关 HFSR 提供参考。方法 根据“5S”证据资源金字塔模型，采用计算机系统检索 UpToDate，乔安娜布里格斯研究所（Joanna Briggs Institute，JBI）循证卫生保健中心数据库，国际指南协作网（Guidelines International Network，GIN），英国国家医疗保健优化研究所（National Institute for Health and Care Excellence，NICE），欧洲肿瘤内科学会（European Societyfor Medical Oncology，ESMO），苏格兰校际指南网（Scottish Intercollegiate Guidelines Network，SIGN），美国肿瘤协会（AmericanSociety of Clinical Oncology，ASCO），美国肿瘤护理学会（Oncology Nursing Society，ONS），加拿大安大略注册护士协会（RegisteredNurses Association of Ontario，RNAO），美国国立综合癌症网络（National Comprehensive Cancer Network，NCCN），Cochrane Library，Embase，Web of Science，OVID，PubMed，医脉通指南网，中国知网，万方，维普，中国生物医学文献数据库中肝癌靶向药物相关HFSR 管理的相关证据，检索时限为 2012 年 1 月至 2024 年 12 月。由 4 名经过循证护理培训的研究者独立对纳入文献进行质量评价，并进行交叉核对，根据证据汇总原则提取证据。结果 共纳入 10 篇文献，包括临床决策 1 篇、指南 4 篇、专家共识 3 篇、证据总结 1 篇、随机对照试验 1 篇，从组织管理、基线评估、预防处理、鉴别诊断、症状处理、健康教育 6 个方面形成 25 条证据。结论 本研究总结的肝癌靶向药物相关 HFSR 预防与管理最佳证据，可为临床医护人员预防及管理 HFSR 提供参考。

Objective To retrieve and synthesise evidence on the prevention and management of hand-foot skin reactions （HFSR）in patients receiving targeted-drug therapy for hepatocellular carcinoma（HCC），so as to provide a reference for clinical practice. Methods Based on the pyramid model，desktop systematic search was conducted across the following databases：UpToDate， Joanna Briggs Institute（JBI）Evidence-Based Practice Database，Guidelines International Network（GIN），National Institute for Health and Care Excellence（NICE），European Society for Medical Oncology（ESMO），Scottish Intercollegiate Guidelines Network（SIGN）， American Society of Clinical Oncology（ASCO），Oncology Nursing Society（ONS），Registered Nurses’Association of Ontario（RNAO）， National Comprehensive Cancer Network（NCCN），Cochrane Library，EMbase，Web of Science，OVID，PubMed，Medlive，China National Knowledge Infrastructure（CNKI），Wanfang Data，VIP Chinese Science and Technology Periodical Database and SinoMed， from January 2012 to December 2024，for literature on the prevention and management of hand-foot skin reactions induced by targeteddrugs for liver cancer. Four researchers trained in evidence-based nursing independently evaluated and cross-checked the quality of the included literature，and extracted the evidence according to the principles of evidence summarisation. Results A total of 10 articles were included：one clinical decision，four guidelines，three expert consensuses，one evidence summary，and one randomised controlled trial. Six domains were identified（organisational management，baseline assessment，preventive treatment，differential diagnosis，symptom management and health education），and 25 evidence statements were synthesised. Conclusion This study summarises the evidence on prevention and management and prevention of HFSR induced by HCC targeted-drugs，and provides healthcare providers with a practical reference for developing tailored management strategies.